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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
19.39
Human Site:
S417
Identified Species:
42.67
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
S417
E
S
R
D
H
G
A
S
W
F
K
K
A
F
E
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
S418
E
S
R
D
H
G
A
S
W
F
K
K
A
F
E
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
H380
G
H
R
E
Q
A
Y
H
W
Y
R
K
A
F
D
Dog
Lupus familis
XP_533420
1645
181128
S688
E
S
R
D
H
G
A
S
W
F
K
K
A
F
E
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
S424
E
S
R
D
H
G
A
S
W
F
K
K
A
F
E
Rat
Rattus norvegicus
XP_001073260
1338
150427
S388
E
S
R
D
H
G
A
S
W
F
K
K
A
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
S367
H
L
R
V
I
Q
A
S
E
K
L
F
K
L
K
Chicken
Gallus gallus
XP_419725
1260
143069
F367
S
Y
W
E
V
G
S
F
L
A
A
S
M
L
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
H404
N
S
R
D
Q
G
I
H
W
F
R
R
G
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
L368
L
I
G
K
K
G
S
L
S
S
L
S
E
Y
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
K370
L
N
N
L
L
G
K
K
G
S
L
V
S
L
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
33.3
100
N.A.
100
100
N.A.
20
6.6
N.A.
53.3
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
60
100
N.A.
100
100
N.A.
26.6
20
N.A.
66.6
N.A.
20
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
55
0
0
10
10
0
55
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
55
0
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
46
0
0
19
0
0
0
0
10
0
0
0
10
0
64
% E
% Phe:
0
0
0
0
0
0
0
10
0
55
0
10
0
64
0
% F
% Gly:
10
0
10
0
0
82
0
0
10
0
0
0
10
0
0
% G
% His:
10
10
0
0
46
0
0
19
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
10
0
10
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
10
0
10
10
0
10
46
55
10
0
10
% K
% Leu:
19
10
0
10
10
0
0
10
10
0
28
0
0
28
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
10
10
10
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
19
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
73
0
0
0
0
0
0
0
19
10
0
0
0
% R
% Ser:
10
55
0
0
0
0
19
55
10
19
0
19
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
10
10
0
0
0
0
0
0
10
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
64
0
0
0
0
0
10
% W
% Tyr:
0
10
0
0
0
0
10
0
0
10
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _